Complexities of Cancer Research: Mouse Genetic Models

Mouse models for cancer research

Mouse models of cancer enable researchers to learn about tumor biology in complicated and dynamic physiological systems. Since the development of gene targeting in mice, cancer biologists have been among the most frequent users of transgenic mouse models, which have dramatically increased knowledge about how cancers form and grow. The Chinese Journal of Cancer will publish a series of papers re...

Genetic Mouse Models for Osteoarthritis Research

SnapShot: Genetic Mouse Models of Cancer

p 53 T um o r S up p re ss o r Trp53 mouse germline knockout. Trp53−/− homozygous: 100% tumor penetrance at ?4.5 months. Typical tumors: T cell lymphoma (>60%); soft tissue sarcoma (?25%); osteosarcoma, brain tumors, teratoma (together <15%); carcinomas rarely observed. Trp53+/− heterozygous: 50% tumor penetrance at 17 months. Typical tumors: T cell lymphoma (?30%); soft tissue sarcoma (?30%); ...

phylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran

in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...

Mouse orthotopic models for bladder cancer research.

Bladder cancer is a common malignancy in the urinary tract. Despite different therapeutic options, recurrence and progression of urothelial carcinoma after treatment is not uncommon. Novel therapeutic options of bladder cancer are urgently needed. The preclinical evaluation of new treatments requires an animal tumour model that mimics the human counterpart. To date, various animal orthotopic bl...